Internet Electronic Journal of Molecular Design - IEJMD, ISSN 1538-6414, CODEN IEJMAT

ABSTRACT - Internet Electron. J. Mol. Des. July 2002, Volume 1, Number 7, 367-373

Quantitative Descriptor for SNP Related Gene Sequences Ashesh Nandy, Papiya Nandy, and Subhash C. Basak Internet Electron. J. Mol. Des. 2002, 1, 367-373

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Abstract:
The rapid growth of DNA sequence information relating to various gene sequences makes it imperative to have quantitative measures to compare and contrast the different sequences. This is of special relevance to libraries of single nucleotide polymorphic (SNP) genes. We had presented a scheme earlier for characterizing a given DNA sequence by a numerical descriptor. We had also shown that the sensitivity of the descriptor to small changes in a given sequence renders it suitable for using it as a parameter to index toxicity levels of various chemicals that induce changes in DNAs. Here we propose that such descriptors can be used to index SNP related genes and show by way of application with simulated changes in human beta-globin gene that very small changes in base composition can lead to identifiable changes in a DNA descriptor. This scheme identifies the relationship of one member of the SNP gene family with another in terms of exact location and nature of changes in the sequence. Such a scheme will be useful in compilation, identification and distribution of genetic variation data on SNP related gene sequences.

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