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Internet Electronic Journal of Molecular Design - IEJMD, ISSN 1538-6414, CODEN IEJMAT
| ABSTRACT - Internet Electron. J. Mol. Des. August 2004, Volume 3, Number 8, 499-513 |
Computers and Humans in the SAR Assessment of Health Hazards
Herbert S. Rosenkranz
Internet Electron. J. Mol. Des. 2004, 3, 499-513
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Abstract:
The SAR-generated toxicological profile of gabapentin was
subjected to human scrutiny and compared to experimentally
derived data. When both experimental data and SAR
projections were available, there was excellent concurrence.
The SAR projections together with analyses of their basis
indicate that GBP is not likely to present a carcinogenic hazard
by mechanisms relevant to humans. The analyses emphasize
the importance of human expertise in interpreting and
accepting SAR predictions of toxicological effects.
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