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Internet Electronic Journal of Molecular Design - IEJMD, ISSN 1538-6414, CODEN IEJMAT
| ABSTRACT - Internet Electron. J. Mol. Des. May 2002, Volume 1, Number 5, 227-235 |
Relationship of Sister Chromatid Exchanges, Genotoxicity and
Carcinogenicity: An SAR-based Analysis
Herbert S. Rosenkranz
Internet Electron. J. Mol. Des. 2002, 1, 227-235
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Abstract:
The ability of chemicals to induce sister chromatid exchanges (SCEs) in cultured cells
has been taken as indicating a potential for causing cancers. Tests for the ability to induce
SCEs are widely used and are part of guidelines for submissions to regulatory agencies.
In the present study, based upon SAR analyses of 10,000 agents representative of the
"universe of chemicals", it is shown that the induction of SCEs is not highly predictive of
the ability to cause cancers. It is further shown that the reason for this lack of predictivity
is due to the fact that SCEs can be induced through mechanisms unrelated to the
carcinogenic process.
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