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Internet Electronic Journal of Molecular Design - IEJMD, ISSN 1538-6414, CODEN IEJMAT
ABSTRACT - Internet Electron. J. Mol. Des. October 2002, Volume 1, Number 10, 545-558

Investigations on Evolutionary Changes in Base Distributions in Gene Sequences
Ashesh Nandy
Internet Electron. J. Mol. Des. 2002, 1, 545-558

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Abstract:
We had observed that 2D graphical plots of DNA sequences show apparently systematic variations among members of families of gene sequences and reported these to be due to evolutionary changes. Investigations of phylogenetic relationships between species through studies of gene sequences has been one of the prime areas of interest to molecular biologists. While questions such as rate of mutational changes in DNA sequences have been investigated extensively, attention is being given recently to changes in base distribution within such sequences. Roman-Roldan et al. has shown that complexity of base organization in intron segments increases with evolution. We use the 2D graphical representation method to map the DNA sequences and use four numerical techniques to quantitatively measure the differences observed in the different gene sequences. We report here our investigations using a graphical technique for DNA sequence representation and related analyses for conserved gene sequences such as kinetoplasts, heat shock proteins, globins and others. We find that there are strong indications that base composition and distributions in protein coding regions progresses with evolution towards an equi-proportional composition and more complex mixing of the four nucleotides which we term as asymptotic complexity. Thus it is possible that increase in base mixing complexity is a general feature of the evolution of gene sequences.

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